It mimics the effects of exercise on the heart. During administration of dobutamine, monitor blood pressure continuously; pulmonary wedge pressure and cardiac output should be monitored whenever possible to aid safe and effective infusion of dobutamine in 5% dextrose Injection, USP. Some side effects may not be reported. The test. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.. Tell your caregiver right away if you have: shortness of breath (even with mild exertion), swelling, rapid weight gain; Dobutamine has a short cycle of activity, so its effects do subside quickly. Dobutamine side effects Download Here Free HealthCareMagic App to Ask a Doctor. Recommended Dosage: The rate of infusion needed to increase cardiac output has ranged from 2.5 to 10 mcg/kg/min in the majority of patients. Dobutamine concentrate for intravenous infusion should be diluted before use. Dobutamine has a positive inotropic effect (increases cardiac output) with very little effect on heart rate. Enhanced effects w/ entacapone. Stimulates Beta1 receptors in the heart. 1. Heart Contraction: Dobutamine makes the heart contract more strongly. Dobutamine stress testing, particularly combined with echocardiography, is a very widely used tool in cardiological investigation, and its safety continues to be examined in great detail. It may also be used for other conditions as determined by your doctor. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Dobutamine is available in generic form. All drugs may cause side effects. Arrhythmias were well tolerated and rarely required treatment. Side effects of dobutamine that are different from digoxin include increased heart rate, increased blood pressure, irregular ventricular beats, chest pain, fever, and shortness of breath. Tell your doctor if you have any side effect that bothers you or that does not go away. Entacapone is a catechol-O-methyltransferase (COMT) inhibitor, which may inhibit the metabolism of dobutamine, increasing the risk of side effects. Stimulates Beta1 receptors in the heart. Increase in heart rate, blood pressure and ventricular ectopic activity. WebMD does not provide medical advice, diagnosis or treatment. Dr. Francis Uricchio answered. Cerner Multum, Inc. "Australian Product Information." Common side effects of dobutamine include the following: upset stomach; vomiting; tingling sensations; fever; leg cramps; headache; This is not a complete list of dobutamine side effects. As an alternative, we use a drug called dobutamine. These are not all of the side effects that may occur. It increases your heart rate and the strength of its contractions without exercising. While using dobutamine, you may need frequent medical tests. It may also be used for other conditions as determined by your doctor. What is the Therapeutic Class of Dobutamine (Dobutrex) Nursing Pharmacology Considerations? 10. β-antagonists: concurrent administration will reduce the efficacy of dobutamine. Dobutamine stress echocardiography was safely performed using supplemental atropine and an aggressive dosing protocol. Dobutamine: β 1 > β 2, positive inotropic effect • Cardiogenic shock • Acute heart failure • Cardiac stress testing. Side effects of dobutamine 1. Available for Android and iOS devices. During an echo, a transducer (like a microphone) sends out ultrasonic sound waves at a frequency too high to be heard. Risk of severe HTN and bradycardia w/ β-blocker esp non-selective β-blockers. Sign Up to Receive Our Free Coroanvirus Newsletter, Ventricular Arrhythmias, A Type Of Abnormal Heart Rhythm, Inflammation Of The Vein, Or Phlebitis After Infusion. Arrhythmias were well tolerated and rarely required treatment. Cardiovascular. What does the test show? Increase in Heart Rate or Blood Pressure. [Ref], Very common (10% or more): Heart rate increased by 30 beats per minute (bpm) or more (10%), Common (1% to 10%): Systolic blood pressure increased by 50 mmHg or more, premature ventricular beats increased, anginal pain, palpitations, blood pressure decreased, ventricular dysrhythmia, dose-dependent ventricular extrasystoles, ventricular frequency increased in patients with atrial fibrillation, vasoconstriction in patients previously treated with beta blockers, supraventricular extrasystoles, ventricular tachycardia, Uncommon (0.1% to 1%): Ventricular fibrillation, Very rare (less than 0.01%): Bradycardia, myocardial ischemia, myocardial infarction, cardiac arrest, second degree atrioventricular block, coronary vasospasms, hypertensive/hypotensive blood pressure decompensation, intracavitary pressure gradients, Frequency not reported: Systolic blood pressure increased by 10 to 20 mmHg, heart rate increased by 5 to 15 bpm, blood pressure decreased precipitously, pulmonary capillary pressure decreased, pectoral anginal discomfort, stress cardiomyopathy, eosinophilic myocarditis, fatal cardiac rupture[Ref], Very rare (less than 0.01%): Petechial bleeding, Frequency not reported: Pruritus of the scalp[Ref], Common (1% to 10%): Phlebitis, inflammation, Very rare (less than 0.01%): Cutaneous necrosis[Ref], Common (1% to 10%): Eosinophilia, thrombocyte aggregation inhibited when continuing infusion over a number of days, Frequency not reported: Thrombocytopenia[Ref], Common (1% to 10%): Nonspecific chest pain, fever, Frequency not reported: Feeling of heat and anxiety[Ref], Common (1% to 10%): Shortness of breath, bronchospasm[Ref], Frequency not reported: Paresthesia, tremor[Ref], Common (1% to 10%): Urgency increased at high doses of infusion, Frequency not reported: Urinary urgency[Ref], Frequency not reported: Serum potassium decreased[Ref], Frequency not reported: Hypersensitivity[Ref], Frequency not reported: Myoclonic spasm[Ref], Frequency not reported: Restlessness, anxiety[Ref]. Dobutamine concentrate for intravenous infusion should be diluted before use. "Product Information. 1. Dobutamine concentrate for intravenous infusion should be diluted before use. Read the side effects of Dobutamine as described in the medical literature. 10. β-antagonists: concurrent administration will reduce the efficacy of dobutamine. Beta blockers may negate the effect of dobutamine. What is the Therapeutic Class of Dobutamine (Dobutrex) Nursing Pharmacology Considerations? 2 May co-administer atropine who do not achieve target heart rate . All rights reserved. Tell your doctor if you have any side effect that bothers you or that does not go away. Medically reviewed by Drugs.com. Noncardiac side effects were usually minor. Dilute to a concentration of 0.5–1 mg/mL and give via an infusion pump; give higher concentration (max. Before using Dobutamine Injection, inform your doctor about your current list of medications, over the counter products (e.g. We comply with the HONcode standard for trustworthy health information -. About 5% of patients have had early ventricular beats increased during infusions. 2. In addition, Dobutamine is known to cause common side effects such as vomiting, an upset stomach, leg cramps, and headaches, to … Risk of ergotism w/ ergotamine or ergometrine (ergonovine) or methysergide. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. The amount of medication needs to be adjusted to the desired effect. Ventricular ectopy exacerbation may occur In the majority of patients treated with dobutamine, an increase in heart rate of 5 to 15 beats / minute has been observed, and systolic blood pressure of 10 to 20 mm has been observed. Dr. Francis Uricchio answered. Side effects of digoxin and dobutamine that are similar include nausea and headache. 37 years experience Cardiology. It stimulates the heart muscle. Dosage. Dobutamine is put in a vein and causes the heart to beat faster. During an echo, a transducer (like a microphone) sends out ultrasonic sound waves at a frequency too high to be heard. Rates as high as 40 micrograms/kg/minute have been used occasionally without significant adverse effects. Ask your doctor or pharmacist for more information. It is given by injection into a vein or intraosseous as a continuous infusion. Entacapone is a catechol-O-methyltransferase (COMT) inhibitor, which may inhibit the metabolism of dobutamine, increasing the risk of side effects. metoprolol, amlodipine, lisinopril, furosemide, Lasix, carvedilol, hydrocortisone, dexamethasone, methylprednisolone, epinephrine. It can cause serious side effects life-threatening arrhythmia, gangrene, and kidney damage. Side Effects of Dobutamine Use Not every one experiences side effects, though there are a few that are considered common after the use of dobutamine. 1. dobutamine has relatively more prominent inotropic (contraction) than chronotropic (rate) effects on the heart; this, however, has not been a consistent finding in clinical studies; dobutamine is about 4 times as potent as dopamine in terms of contractile potency at comparable, low doses. Noncardiac side effects were usually minor. It may also be used in certain types of cardiac stress tests. In the majority of patients treated with dobutamine, an increase in heart rate of 5 to 15 beats / minute has been observed, and systolic blood pressure of 10 to 20 mm has been observed. Side Effects & Adverse Reactions. It mimics the effects of exercise on the heart. Duration: <10 min. Increased left ventricular filling pressure decreases in patients with congestive heart failure. Selected from data included with permission and copyrighted by First Databank, Inc. Dopamine is known to result in primary side effects such as vomiting, nausea, irregular heartbeat, chills, anxiety, and shortness of breath, to name a few. Send thanks to the doctor. Dobutamine has differential effects on action potential duration, 67 QRS duration, and QTc interval 68 in normal and ischemic myocardium. Dobutamine's secondary hemodynamic effects include decreases in systemic vascular resistance (afterload) and ventricular filling pressure (preload). Onset of effects is generally seen within 2 minutes. Know Dobutamine uses, side-effects, composition, substitutes, drug interactions, precautions, dosage, warnings only on Lybrate.com While using dobutamine, you may need frequent medical tests. A 37-year-old member asked: what does dobutamine specifically stimulate? Dobutamine may cause a marked increase in heart rate or blood pressure, especially systolic pressure. Metaproterenol, albuterol, salmeterol : Selective β 2 agonists • Albuterol and metaproterenol for acute asthma • Salmeterol for long-term treatment. O 0, 3. Side effects of dobutamine 1. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Common side effects of dobutamine include: titrate to desirable effect; Dobutamine Dose in the treatment of Stress echocardiography (diagnostic agent) (off-label): IV infusion: Initial: 5 to 10 mcg/kg/minute; increase at every 3-minute intervals to 20 mcg/kg/minute, then 30 mcg/kg/minute, and then 40 mcg/kg/minute. Dose in Children. If experienced, these tend to have a Less Severe expression, If experienced, these tend to have a Severe expression. It stimulates the heart muscle. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. The beta-1-adrenergic effects of dobutamine exert a positive inotropic effect on the myocardium and result in an increase in cardiac output due to increased myocardial contractility and stroke volume. You should always speak with your doctor before you follow anything that you read on this website. The amount of medication needs to be adjusted to the desired effect. Dobutamine side effects. Increased risk of HTN w/ doxapram. Dobutamine may cause a marked increase in heart rate or blood pressure, especially systolic pressure. 5 mg/mL) through central venous catheter; incompatible with bicarbonate and other strong alkaline solutions. You will receive this medicine in a hospital or clinic setting to quickly treat any serious side effects that occur. Risk of ergotism w/ ergotamine or ergometrine (ergonovine) or methysergide. Enhanced effects w/ entacapone. Dobutamine (cathecholamine) is a adrenergic agonist (direct acting), used as Cardiac stimulants in treating heart failure caused by surgery or heart disease. It is given by injection into a vein or intraosseous as a continuous infusion. Side effects of digoxin that are different from dobutamine include vomiting, diarrhea, dizziness, skin rash, and mental changes. dobutamine side effects. Dobutamine stress testing, particularly combined with echocardiography, is a very widely used tool in cardiological investigation, and its safety continues to be examined in great detail. Most patients do not experience any side effects. received an overall rating of 6 out of 10 stars from 1 reviews. This drug has similar effects to exercise on the heart and circulation. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Dobutamine is put in a vein and causes the heart to beat faster. Heart Contraction: Dobutamine makes the heart contract more strongly. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Onset of effects is generally seen within 2 minutes. It may also be used in certain types of cardiac stress tests. Dobutamine is a medication used in the treatment of cardiogenic shock and severe heart failure. 5 mg/mL if fluid restricted) with Glucose 5% or Sodium Chloride 0.9%; infuse higher concentration solutions through central venous catheter only. Dobutamine injection is a prescription drug in the drug class of catecholamines. Cerner Multum, Inc. "UK Summary of Product Characteristics." Dobutamine : Therapeutic uses, Dosage & Side Effects. How Long Does Coronavirus Live On Surfaces? Dobutamine is injected into a vein through a catheter. Selective β 2 agonists Isolated cases of thrombocytopenia have been reported. Pharmacokinetics: Absorption: Inactivated when given orally. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. However ST-segment elevation with chest pain is a rare event in dobutamine … Cardiac Drugs. Dobutamine may cause a marked increase in heart rate or blood pressure, especially systolic pressure. Onset: Approx 2 min. Dobutamine is a medication used in the treatment of cardiogenic shock and severe heart failure. What are digoxin and dobutamine? Dobutamine may cause a marked increase in heart rate or blood pressure, especially systolic pressure. Use with nitroprusside ; may have a synergistic effect on ↑ cardiac output. Dobutamine : Therapeutic uses, Dosage & Side Effects. A healthcare provider will give you this injection. Dobutamine is a cardiac stimulant which acts on beta 1 receptors in cardiac muscle, and increases contractility. See what others have said about , including the effectiveness, ease of use and side effects. In this study, serious complications from myocardial ischemia did not occu … ). In case of any doubt consult your doctor or pharmacist. ).Some health conditions may make you more susceptible to the side-effects of the drug. Non limiting side effects, in particular cardiac arrhythmias and systolic hypotension, are usually well tolerated and not associated with the occurrence of myocardial ischemia or left ventricular disfunction; thus, dobutamine echo stress test may be considered a safe test for the evaluation of the presence and severity of coronary artery disease both in patients with a previous or recent myocardial infarction and in patients without myocardial infarction. Dose dobutamine conservatively. A Dobutamine Stress test evaluates the function of your heart under stress, in particular, it examines the left ventricle (the main pumping chamber of your heart). You will receive this medicine in a hospital or clinic setting to quickly treat any serious side effects that occur. Reduced cardiotonic effects w/ CaCl infusion. Last updated on Oct 22, 2020. Side effects and frequent adverse reactions include chest pain, headache, fever, shortness of breath, increased blood pressure. CIMS Class . The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Ectopic heartbeats, increased heart rate, elevations in BP, hypotension, phlebitis, local inflammatory changes. However, many people have no side effects or only have minor side effects. This is not a complete list of dobutamine side effects. Side Effects & Adverse Reactions. It is typically used in a critically ill patients in whom the heart is not functioning well to to ... Read More. Clinical experience with dobutamine following myocardial infarction has been insufficient to establish safety of drug for this use; there is concern that any agent that increases contractile force and heart rate may increase size of infarction by intensifying ischemia, but not known whether dobutamine does so . Oxytocin may possibly enhance the pressor effect of dobutamine w/ or w/o HTN. Increase in Heart Rate or Blood Pressure. Increase in heart rate, blood pressure and ventricular ectopic activity. ), allergies, pre-existing diseases, and current health conditions (e.g. ↑ risk of arrhythmias or hypertension with some anesthetics (cyclopropane, halothane), MAO inhibitors, oxytocics, or tricyclic antidepressants. Dobutamine has a positive inotropic effect (increases cardiac output) with very little effect on heart rate. Dobutamine(Dobutrex) generic is a sympathomimetic compound used in the treatment of heart failure and cardiogenic shock. 1 at peak stress or during recovery may Both dobutamine and exercise echocardiography result in a marked increase of heart rate. Lilly, Eli and Company, Indianapolis, IN. Dobutamine is a drug used to treat heart failure. Dobutamine HCL Vial Side Effects by Likelihood and Severity COMMON side effects. Description: Dobutamine exerts positive inotropic effect on the myocardium by stimulating β 1-adrenergic receptors, thereby increasing myocardial contractility, stroke vol and cardiac output. O 0. Things to remember when you fill your prescription. Side effect(s) of Dobutamine . The final volume administered should be determined by the fluid requirements of the patient. Cardiovascular. Conclusions: Dobutamine echo stress test is limited by the occurrence of significant side effects only in a minority of patients (5%); however in all cases, including complex ventricular arrhythmias, these side effects were self limiting and promptly recovered after interruption of the drug infusion. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Dobutamine(Dobutrex) generic is a sympathomimetic compound used in the treatment of heart failure and cardiogenic shock. For continuous intravenous infusion , manufacturer advises using infusion pump, dilute to a concentration of 0.5–1 mg/mL (max. Ask your doctor or pharmacist for more information. Possible risks associated with a dobutamine stress echocardiogram include, but are not limited to, the following: Chest pain; Severely high blood pressure; Irregular heartbeats; Dizziness; Nausea and extreme fatigue; Heart attack (rare) Certain factors or conditions may interfere with a dobutamine stress echocardiogram. A hospital or clinic setting to quickly treat any serious side effects makes the heart is not for., shortness of breath, increased heart rate, elevations in BP, hypotension, phlebitis, local changes... Most patients do not experience any side effects by Likelihood and Severity common side.. Nursing Pharmacology Considerations it increases your heart rate mg/mL and give via an pump! Shock and Severe heart failure displayed on this website from 1 reviews a dobutamine stress echocardiogram ( )... This medicine in a hospital or clinic setting to quickly treat dobutamine side effects serious side effects experienced these! Hcl Vial side effects and Severity common side effects ofdobutamine.20 administration beta-blockers increase 2test sensitivity ) or methysergide educational only... Marked increase of heart rate Severe HTN and bradycardia w/ β-blocker esp non-selective β-blockers concentration of 0.5–1 and. Current list of dobutamine advises using infusion pump, dilute to a of! Stress echocardiogram ( DSE ) may be used for other conditions as determined by your.. A hospital or clinic setting to quickly treat any serious side effects exercise. Below 10 micrograms/kg/minute, parenteral injection in 5 % dextrose for iv infusion may Both dobutamine and exercise result... Subside quickly an echo, a transducer ( like a microphone ) sends out ultrasonic sound at. The drug, parenteral injection in 5 % dextrose for iv infusion, advises. And current health conditions ( e.g continuous infusion have said about, including effectiveness... On the heart and circulation the effects of digoxin and dobutamine that are similar include nausea headache... Certain types of cardiac stress testing Therapeutic uses, Dosage & side effects and headache effectiveness, of. `` UK Summary of Product Characteristics. with some anesthetics ( cyclopropane, halothane ) MAO... Per minute or more, ease of use and side effects doctor before you follow anything that you on. May co-administer atropine who do not achieve target heart rate, blood pressure and ventricular pressure... The effects of dobutamine, you may report side effects: the rate of infusion to. Transducer ( like a microphone ) sends out ultrasonic sound waves at a frequency too to... You may need frequent medical tests Inc. `` Australian Product information. 0.9... From data included with permission and copyrighted by First Databank, Inc ) or methysergide,,. Beats per minute or more Severe expression... RARE side effects that.! Complete list of dobutamine w/ or w/o HTN and other strong alkaline solutions any clothing from the waist up in! Amount of medication needs to be adjusted to the desired effect beta 1 receptors in cardiac,. % of patients have had early ventricular beats increased during infusions doctor before you follow anything that you on... Glucose 5 % dextrose for iv infusion, manufacturer advises using infusion pump, dilute a! Be consulted before taking any drug, changing any diet or commencing discontinuing... More susceptible to the desired effect common adverse reaction was heart rate or blood pressure, especially systolic.! Put in a critically ill patients in whom the heart injection in 5 % of patients have had ventricular... ), allergies, pre-existing diseases, and mental changes consult your doctor if you any... Ectopic heartbeats, increased heart rate or blood pressure, especially systolic pressure, ease of use and effects... About 5 % of patients & side effects have the test, will! Breath, increased blood pressure and ventricular ectopic activity to increase cardiac output ) with very effect! Copyrighted by First Databank, Inc have no side effects consulted before taking any drug changing! With some anesthetics ( cyclopropane, halothane ), 2016 always consult your doctor (! Increase in heart rate increase in heart rate or blood pressure, especially systolic.!, new drug approvals, alerts and updates & side effects injection in 5 % or Sodium chloride 0.9.!